1. Go to whatever the 4th quadrant is called. (Beta Quadrant?) After all, the show has been to the Alpha, Delta, and Gamma Quadrants.
2. Set the new series in the future. (Maybe on a timeship?)
3. Open up other galaxies; maybe the Q become satisfied that humans are ready, and lift the galactic barrier and then we can have a Star Trek: Andromeda Galaxy. Or something like that.
4. Have the crews of two previous series meet up on a permanent basis?
5. Maybe the Borg become a member of the Federation. (Okay, that one was just for giggles.:-)
6. This space intentionally left blank.